Matrix-induced Autologous Chondroctye Implantatation (MACI)

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What is MACI?

​MACI (Matrix-Induced Autologous Chondrocyte Implantation) is an advanced cartilage restoration technique used to treat cartilage defects in the knee. It involves harvesting a patient’s own cartilage cells (chondrocytes), culturing them in a lab to increase their number, and then implanting them back into the damaged area using a specialized collagen membrane.

How does MACI work?

1. Cartilage Biopsy: During an initial arthroscopic procedure, a small sample of healthy cartilage is taken from a non-weight-bearing area of the knee.
2. Cell Culturing: The harvested cells are sent to a lab where they are cultured and grown on a collagen membrane over several weeks.
3. Implantation: In a second surgery, the collagen membrane, now embedded with millions of new cartilage cells, is implanted into the defect and secured with a fibrin sealant.
4. Healing: The cells integrate with the surrounding cartilage, gradually restoring the joint surface.

​Benefits of MACI

• Personalized Treatment: Uses the patient’s own cells to regenerate cartilage.
• Long-Term Results: Proven effectiveness in improving knee function and reducing pain.
• Minimally Invasive Harvesting: The initial biopsy is done arthroscopically, minimizing tissue damage.
• Versatile: Suitable for various cartilage defects, especially in active patients.​

Who is a Good Candidate for MACI?

• Defects usually 1.5-2cm or greater in size
• Individuals with symptomatic cartilage defects in the knee.
• Patients who have not responded to conservative treatments such as physical therapy or injections.
• Typically suited for younger, active patients with isolated cartilage damage.
• Those who wish to maintain an active lifestyle post-surgery.

Recovery and Rehabilitation

Every patient will have an individual treatment plan based off the location and size of the defect. 
In general, the following are a good guide for what to expect 

• Initial Phase: Limited weight-bearing and use of crutches for 6-8 weeks.
• Physical Therapy: Begins immediately, focusing on maintaining knee mobility.
• Strengthening Phase: Gradual increase in load-bearing and strengthening exercises.
• Return to Activities: Light activities after 3-6 months, with full return to sports around 9-12 months.​
  

Schedule a Consultation for MACI

​If you’re experiencing knee pain and want to explore advanced cartilage restoration options like MACI, contact our office today to schedule a consultation.  To see our office locations and contact, click here